3rd ISN Latin American School of Advanced Neurochemistry

3rd ISN Latin American School of Advanced Neurochemistry

El objetivo de este curso de postgrado es proveer una plataforma científica enfocada al planteo y realización de diferentes aproximaciones neuroquímicas utilizadas en la investigación preclínica para el estudio de patologías del sistema nervioso central. Dicha plataforma se basará en conferencias, experiencias prácticas y seminarios de discusión.

 

Acerca de células dendrítricas

Acerca de células dendrítricas. A los interesados en asistir se les ruega tengan a bien inscribirse a la siguiente dirección de e-mail: asensio.cristian@live.com.ar
 

Seminario en BIOMED: The activation of the inflammasomes in host response to intracellular pathogens

The activation of the inflammasomes in host response to intracellular pathogens. A los interesados en asistir se les ruega tengan a bien inscribirse a la siguiente dirección de e-mail: asensio.cristian@live.com.ar
 

Seminario en BIOMED: Pseudomonas aeruginosa: procesos de adhesión, invasión y multicelularidad en su interacción con células

Pseudomonas aeruginosa: procesos de adhesión, invasión y multicelularidad en su interacción con células epiteliales
 

Seminario en BIOMED: Are dendrites neuronal substrates for central autonomic-neuroendocrine integration? Possible physio-path

The hypothalamic paraventricular nucleus (PVN) is a major brain center involved in the integration of autonomic and neuroendocrine functions, and heavily involved in the maintenance of bodily homeostasis. Moreover, an imbalanced activity of these two systems is now acknowledged to be a critical underlying pathophysiological event in prevalent human diseases, including hypertension, heart failure, and the metabolic syndrome. Despite this, the precise mechanisms underpinning neuroendocrine and autonomic integration in the PVN remain largely unknown. Dendrites have been classically considered the receptive assemblies in neurons. However, the recent discovery that dendrites are excitable and capable of releasing signaling molecules, particularly neuropeptides, indicate that they actively participate in information processing in the brain. In this presentation I will summarize recent work from our laboratory showing that dendritic release of neuropeptides, particularly vasopressin, serves as a novel signaling modality mediating crosstalk between neurosecretory and sympathetic neurons in the PVN, which in turn is critical for the generation of multimodal homeostatic neurohumoral responses by the PVN. Finally, I will discuss how changes in this novel signaling mechanism may contribute to exacerbated neurohumoral activation in disease states.
 

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